Chosen Solution

I’m leaving on a short vacation and I’m wondering if I have to take my book with me along with my laptop? And if not when I come back can I just plug it back in

You shouldn’t need to! The issue is two fold how much space does your system still have so you can save stuff to your internal drive, then the other side of the issue is if you have stuff on your WD drive that you’ll need. I’m assuming you use your WD mostly as a backup drive (using Time Machine). Maybe you should look at getting a smaller SSD drive if you don’t have much space on your internal drive. I like the Samsung T5 SSD drives very portable! There are others which are similar.